segunda-feira, 31 de março de 2008
Médicos da Mayo Clinic nos EUA estão estudando o uso de Botox para tratamento da Hipertrofia Benigna da Próstata.
quinta-feira, 27 de março de 2008
De acordo com estudos publicados no Journal of Clinical Endocrinology & Metabolism liderado pela Dra. Cristina Wang e com a participação de colegas de outros países como dos EUA, China, Austrália, Alemanha e Itália, foram encontradas evidências de que se é possível diminuir a contagem de espermatozóides com a administração de hormônios como testosterona e associações androgênio- progesterona.
Leia artigo na íntegra, publicado na MedPage Today:
quarta-feira, 26 de março de 2008
terça-feira, 25 de março de 2008
segunda-feira, 24 de março de 2008
quinta-feira, 20 de março de 2008
Estudos sugerem, que a circuncisão pode não ter o efeito protetor contra Doenças Sexualmente Transmissíveis.
Leia o artigo na íntegra, publicado na Reuters:
quarta-feira, 19 de março de 2008
terça-feira, 18 de março de 2008
segunda-feira, 17 de março de 2008
sexta-feira, 14 de março de 2008
Uma droga experimental pode diminuir o sintoma de micção noturna, no paciente que sofre de crescimento da próstata.
quinta-feira, 13 de março de 2008
Hoje em dia existe um protocolo terapêutico que visa uma recuperação mais rápida da atividade sexual, no paciente que se submeteu a uma cirurgia para a extirpação completa da próstata, no caso de câncer. Essa terapia envolve o início de drogas logo no pós-operatório, de medicamentos que levam a uma fármaco- ereção (Viagra, Cialis, etc) diariamente ou quando do desejo de ter uma relação sexual. Na hora da alta hospitalar, o paciente já recebe a receita do medicamento.
quarta-feira, 12 de março de 2008
terça-feira, 11 de março de 2008
segunda-feira, 10 de março de 2008
quinta-feira, 6 de março de 2008
A migração dos implantes para a braquiterapia pode colocar em risco, o paciente em tratamento para câncer de próstata.
by Lynda Williams
Brachytherapy seed migration may place men at risk of recurrent prostate cancer, a case report published in the journal Prostate Cancer and Prostatic Diseases suggests.
The study describes the management and outcome of a 64-year-old patient with a palpable lesion in both prostate cancer lobes who underwent iodine125 brachytherapy monotherapy with curative intent.
Within a month of treatment, the man's prostate-specific antigen (PSA) level fell from 9 ng/ml to 1.2 ng/ml and reached a nadir of 0.5 ng/ml after 7 months, say lead author Mauro Gacci and team from the University of Florence in Italy.
However, after 2 years of follow-up, the patient's PSA level increased to 18.7 ng/ml and he was found to have a Gleason score 8 prostate cancer concentrated in the right prostatic base.
The patient showed no evidence of metastases and underwent radical prostatectomy with lymph node dissection. One year after surgery, his PSA level was 0.01 ng/ml.
Of note, seeds were identified in the patient's anus muscle and fat tissue, and radiology studies of the prostate revealed that no seeds were present in the right base of the prostate.
Acknowledging that fluoroscopy and dosimetry studies had demonstrated correct seed placement 4 weeks after the procedure, the researchers say that "seed migration from the right base of the prostate was the main cause of tumor relapse in this area, and consequent PSA progression."
They add: "The following PSA remission confirmed the initial correct positioning of the seeds."
quarta-feira, 5 de março de 2008
"Hypertension is an important risk factor of RCC, accounting for approximately 20%-30% of cases," Dr. Steffen Weikert from the German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, told Reuters Health. "Adequate control and prevention of elevated blood pressure may lower the incidence of RCC."
Dr. Weikert and colleagues in the European Prospective Investigation into Cancer and Nutrition examined the relation between blood pressure and risk of RCC, taking into account such other important risk factors as obesity, smoking, and the use of antihypertensive medication.
The study included nearly 300,000 subjects in eight countries, whose blood pressure was measured in 1992-1998. During a mean of 6.2 years of follow-up, 250 cases of RCC occurred.
The risk of RCC was more than doubled for patients in the highest categories of both systolic and diastolic blood pressure (relative risks 2.48 and 2.34, respectively) compared with those in the lowest categories of systolic and diastolic blood pressure, the authors report.
The risk estimates associated with diastolic (but not systolic) blood pressure were somewhat higher for men than for women in the highest category, the report indicates.
There appeared to be no interactions between blood pressure and smoking or body mass index, and, in fact, the increased RCC risk related to obesity was mild and nonsignificant in the absence of markedly elevated blood pressure.
"Individuals taking antihypertensive drugs were not at a significantly increased risk unless blood pressure was poorly controlled," the researchers note.
"Hypertensive kidney damage (scarring/glomerulosclerosis), oxidative stress/lipid peroxidation, and up-regulation of hypoxia inducible factors (HIF) and hypoxia-inducible genes may contribute to malignant transformation/progression," Dr. Weikert explained.
Further studies are planned, Dr. Weikert added, "to characterize the up-regulation of hypoxia-inducible genes and features of lipid peroxidation in adjacent normal renal tissue of RCC patients with a history of hypertension as compared to those without, to investigate the association between biomarkers of lipid peroxidation and RCC, and to study the role of hypertension in relation to prognosis of RCC patients."
terça-feira, 4 de março de 2008
Um estudo realizado na Austrália que avaliou 3.987 homens com idade acima de 70 anos, mostrou que aqueles que apresentavam queda nos níveis sanguíneos do hormônio masculino testosterona, tinham tres vezes mais propensão ao aparecimento de sintomas e sinais de depressão. Embora mais estudos sejam necessários, corrigir os níveis de testosterona nesses casos, pode ser uma forma de corrigir esse problema.
Tudo isso, numa semana em que pesquisas mostraram, que anti-depressivos que vinham sendo usados em larga escala, como Prozac e Zoloft, talvez não tenham nenhuma ação nos casos de depressão leve e/ou moderada.
Leia o artigo publicado na íntegra no BBC News:
'Testosterone link' to depression "
Hormones may alter brain chemistry. Older men with lower levels of the male sex hormone testosterone in their blood may be more prone to depression, a study suggests.
A study of about 4,000 men aged over 70 found those with lowest testosterone were three times more likely to be depressed than those with the most.
Researchers suspect the hormone may affect levels of key brain chemicals.
The study, by the University of Western Australia, features in Archives of General Psychiatry.
It would be no surprise that low testosterone reduces mood
Professor David KendallUniversity of Nottingham
Research has found that women are more likely to be depressed than men until the age of 65, when the difference between the genders almost disappears.
Testosterone levels decline with age - but there is wide variation.
The Australian team studied 3,987 men over the age of 70. Each gave blood samples and took part in tests to determine whether they were depressed.
In total 203 of the participants were assessed as being depressed.
They had significantly lower levels of both total testosterone, and free testosterone, which is not bound to proteins.
The researchers then adjusted the data to take account of factors such as educational attainment and body fat levels.
They found those men whose level of free testosterone was in the bottom 20% were three times more likely to be depressed than those in the top 20%.
The researchers said further work was required to confirm their findings.
But their work raised the possibility that treatment to boost testosterone levels in older men may be an effective way to treat depression.
Raised death risk
A previous study of 800 men over the age of 50 found that those with low levels of testosterone had a 33% increased risk of death over an 18-year period than those with higher levels.
They appeared significantly more likely to have a cluster of risk factors associated with cardiovascular disease and diabetes.
This raises the possibility that men with low testosterone levels may be prone to depression because they are also more likely to be in poor physical health.
However, the Australian researchers concluded that this could not fully explain the link, and that some other factor must also be in play.
Testosterone replacement therapy has also been shown to help elderly men with mild Alzheimer's disease.
Research has suggested that levels of testosterone in men of all ages are falling.
Professor David Kendall, an expert in pharmacology at the University of Nottingham, said there was a wealth of evidence to show that testosterone levels were linked to mood.
For instance, farmers had long castrated their stock to pacify them.
Research on animals had also shown that removal of their gonads blocked the action of anti-depressants on key mood-controlling chemicals in the brain.
"It would be no surprise that low testosterone reduces mood," he said.
"Testosterone therapy offers a relatively simple intervention, potentially, for some groups of older depressives with hypogonadism (low production of sex hormones)."
Professor Stafford Lightman, a hormone expert at the University of Bristol, said testosterone potentially had many small effects which could raise the risk of depression. For instance, low levels had been linked to poor cognitive performance.
However, he warned that depression, particularly in elderly people, was often the result of many different, inter-relating factors, and warned against placing too much emphasis on one in isolation.
"My view is that low testosterone could be a contributory factor to depression, but probably not a very powerful one," he said. "
segunda-feira, 3 de março de 2008
Mas fica a dúvida se esse efeito colateral não estaria sendo produzido pela associação do sildenafil a tóxicos como cocaína, cada vez mais visto nos usuários de drogas nos clubes britânicos.
Porém não foi observado nos estudos com camundongos, qualquer efeito na genética dos filhotes que nasceram daqueles animais, que conseguiram fecundar e que tinham tido o sêmen em contato com o sildenafil em ambiente laboratorial.
Leia o artigo na íntegra, publicado no Daily Mail:
Men who take Viagra could put their fertility at risk, experts warned yesterday.
Researchers say the drug could harm sperm and reduce its ability to fertilise an egg.
They claim fertility clinics prescribing Viagra to men could be reducing their chances of fathering a baby.
Gynaecologist Dr David Glenn said: "It is worrying that some IVF clinics are using Viagra in order to boost fertility results.
"Couples who go there for treatment are, by definition, already having problems getting pregnant. Viagra may simply be making these worse.
"Giving male partners something that could make the problem worse is scarcely the right approach."
His team bathed human sperm in a Viagra solution to give the same exposure as that seen in the blood of a man after taking a pill.
They found Viagra made sperm more active than if it was not exposed to the drug.
But Viagra also damaged the cap-like structure - or acrosome - that contains the chemicals which allow the sperm to break into an egg.
In tests on mice, sperm exposed to Viagra produced 40 per cent fewer embryos.
Since Viagra was launched in 1998, it has been prescribed to 20million men.
Many are middle aged or elderly and unlikely to be concerned about the drug's impact on their ability to have children.
But Dr Glenn, who raised concerns about the impotence drug in 2004, said younger men using it recreationally could have fertility problems later.
Around forty per cent of IVF clinics have used the drug in the last few years. However, some doctors have stopped recommending it because of its reported links with infertility.
"Couples going to clinics already have fertility problem," he added. "Viagra may simply be making these worse."
The studies were carried out in 2004 and published last year in the journal Fertility and Sterility.